Monitoring patients with heart failure, atrial fibrillation and under anticoagulant agent by using telemedicine systems is a potential means for optimizing the management of these patients. The HOCAS project is developing an “intelligent” communicative platform enabling the home monitoring of patients with heart failure, arrhythmias and anticoagulation drugs using non-invasive sensors, electronic pillbox to promote therapy adherence, a questionnaire to monitor patients’ hygiene and diet, a questionnaire to monitor patients’ therapy adherence together with additional contextual information and patients’ profile.